Trends in Helicobacter pylori (H. pylori) and smoking explain a significant proportion of the decline of intestinal-type noncardia gastric adenocarcinoma (NCGA) incidence in U.S. men between 1978 and 2008, and are estimated to continue to contribute to further declines between 2008 and 2040. These are the conclusions of a study from the Center for Health Decision Science at the Harvard School of Public Health (an affiliate of the Dana-Farber Cancer Institute) in Boston, published in PLOS Medicine, that suggest H. pylori and smoking trends together accounted for almost half of the observed decline in intestinal-type NCGA between 1978 and 2008.
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