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Posts Tagged ‘targeting’


Drug Action In Pancreatic Cancer Tracked And Improved By Nanotechnology

UK and Australian scientists have been able to show ways in which we can markedly improve drug targeting of solid tumours, using tiny ‘biosensors’ along with new advanced imaging techniques. In real time and in three dimensions, these technologies can show us how cancers spread and how active cancer cells respond to a particular drug…

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Diabetes drug points the way to overcoming drug resistance in melanoma

Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. Researchers now describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs. Their studies, conducted in cell and animal models of melanoma, demonstrate that the combined therapy could destroy a subset of drug-resistant cells within a tumor.

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A new approach to prostate cancer treatment?

A clinical trial is testing whether targeting treatments to a genetic anomaly can lead to more targeted treatment for prostate cancer. Learn more about this phase 2 trial for men with castration-re…

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Targeting prostate cancer treatment

A new clinical trial is testing whether targeting treatments to a certain genetic mutation can lead to more targeted treatment for prostate cancer. If you or a loved one have metastatic prostate…

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Cervical Cancer Vaccine for primary school girls

Primary school girls across the country will start receiving free cervical cancer vaccines; the government is targeting girls who are aged between 9 and 13 y…

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Dual targeting of metastatic breast cancer improves survival rates

A new study from the USC Norris Comprehensive Cancer Center showed that targeting both hormone receptors (HRs) and human epidermal growth factor receptor 2 (HER2) in first-line treatment of metastatic breast cancer (MBC) patients significantly increased overall survival times.

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New class of drug targets skin cancer

A new class of drug targeting skin cancer’s genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.

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Cancer cell metabolism kills: Possible new therapies targeting energy supply of cancer cells?

Adenosine-5’-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists have found that even a short-term shortage of ATP supply can be fatal for cancer cells because activation of a mitochondria-addressed cell death pathway. These findings may lead to new therapies specifically targeting the altered energy supply chains of cancer cells to get cancer cells to commit suicide.

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Novel small molecules used to visualize prostate cancer

Two novel radiolabeled small molecules targeting prostate-specific membrane antigen have excellent potential for further development as diagnostic and therapeutic radiopharmaceuticals, according to new research. The imaging agents — 123I-MIP-1072 and 123I-MIP-1095 — were shown to have a high sensitivity of lesion detection in bone, soft tissue and the prostate gland with minimal retention in non-target tissue.

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QIMR researchers finding prostate cancer treatments thanks to the Rio Tinto Ride to Conquer Cancer

In Australia, 20000 new cases of prostate cancer are diagnosed each year, and 3000 men die from the disease annually. If detected early, prostate cancer can be treated with surgery and/or radiotherapy. But when the cancer has spread, treatment options are limited. There is an urgent need for new molecular targets for late stage treatments. Eph and ephrin proteins are already know to play a role in cancers like leukaemia, glioma and ovarian cancer and clinical trials targeting the Eph protein EphA3 in leukaemia are underway. This research team will use their Rio Tinto Ride to Conquer Cancer grant to further investigate the role of these proteins in late stage prostate cancer, with a long-term view to developing new targets and treatments.

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