Cancer News, Treatment and Research

Researchers at Mayo Clinic have completed the world’s first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking the genetic secrets of this poorly understood and highly aggressive cancer of the immune system. The researchers, affiliated with Mayo’s Center for Individualized Medicine and Mayo Clinic Cancer Center, found 13 genomic abnormalities that were seen in multiple peripheral T-cell lymphomas. Of particular interest, five of these abnormalities relate to production and behavior of the p53 protein — often called the “guardian of the genome” because of the central role it plays in regulating cell life cycles and, therefore, suppressing cancers.