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Posts Tagged ‘signalling’

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How does pregnancy reduce breast cancer risk?

By on Monday, April 29th, 2013 | No Comments

Being pregnant while young is known to protect a women against breast cancer. But why? New research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

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Vital Clues About Brain Tumors Provided By Virus-Like Particles

By on Saturday, April 20th, 2013 | No Comments

“Current wisdom says that cells are closed entities that communicate through the secretion of soluble signalling molecules. Recent findings indicate that cells can exchange more complex information – whole packages of genetic material and signalling proteins…

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New drug target companion prognostic test for hormone therapy resistance

By on Tuesday, April 2nd, 2013 | No Comments

A team of international cancer researchers has identified the signalling pathway that is over-activated in estrogen receptor-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

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New monoclonal antibody inhibits tumour growth in advanced solid tumours in a phase I clinical trial

By on Wednesday, November 7th, 2012 | No Comments

A newly developed antibody targeting a signalling pathway that is frequently active in solid tumors has shown encouraging signs of efficacy in its first trial in humans, researchers report.

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Cells control energy metabolism via hedgehog signalling pathway

By on Friday, October 12th, 2012 | No Comments

Cancer, diabetes, and excess body weight have one thing in common: they alter cellular metabolism. Scientists have resolved a new molecular circuit controlling cellular metabolism. The previously unknown signalling pathway, acting downstream of the hedgehog protein enables muscle cells and brown fat cells to absorb sugars without relying on insulin. Substances that selectively activate the signalling pathway could thus be utilized in the treatment of diabetes and obesity. With their results, the researchers are also able to explain why various new anti-cancer agents have induced mysterious pronounced side effects in the clinics.

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Modification of tumor suppressor affects sensitivity to potential GBM treatment

By on Tuesday, August 14th, 2012 | No Comments

Biologists and oncologists have long understood that a protein called the epidermal growth factor receptor or EGFR is altered in at least 50 percent of patients with glioblastoma. Yet patients with glioblastoma either have upfront resistance or quickly develop resistance to inhibitors aimed at stopping the protein’s function, suggesting that there is another signalling pathway at play.

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Discovery Of Mechanism That Controls Obesity, Atherosclerosis And Potentially Cancer

By on Friday, July 6th, 2012 | No Comments

A*STAR scientists from the Institute of Molecular and Cell Biology (IMCB) and the Singapore Bioimaging Consortium (SBIC) have discovered a new signalling pathway that controls both obesity and atherosclerosis…

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Groundbreaking discovery of mechanism that controls obesity, atherosclerosis

By on Thursday, July 5th, 2012 | No Comments

Scientists have discovered a new signalling pathway that controls both obesity and atherosclerosis. They have demonstrated that mice deficient in the Wip1 gene were resistant to weight gain and atherosclerosis via regulation of the Ataxia telangiectasia mutated gene and its downstream signalling molecule mTor. These groundbreaking findings may provide significant new avenues for therapeutic interventions for obesity and atherosclerosis.

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New properties of stem cells via simulated microgravity

By on Saturday, June 30th, 2012 | No Comments

A recent study set out to illustrate novel mechanical transduction properties of hematopoietic stem cells in relation to defining the expression of humoral factors by facilitating paracrine/autocrine signalling via microgravity.

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Signalling Protein VEGF Helps Renew Stem Cells In Common Skin Cancer

By on Saturday, October 22nd, 2011 | No Comments

New research from Belgium, published in Nature this week, reveals that VEGF, a signalling protein that is known to regulate the formation of new blood vessels, has a dual role in helping cancer cells grow and form tumors in skin squamous cell carcinoma, a common cancer in humans…

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