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Posts Tagged ‘neuroendocrine’


Inherited Endocrine Tumor Syndrome Linked To Much-Studied Cell Pathway

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1). Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin…

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Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine Tumors

Conditions :   Neuroendocrine Tumors;   Hepatic Metastases;   Metastases Interventions :   Drug: Everolimus;   Device: embolization;   Drug: Doxorubicin Sponsors :   Federation Francophone de Cancerologie Digestive;   Federation Francophone de Cancerologie Digestive Not yet recruiting – verified August 2012

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Researchers test new drug for patients with neuroendocrine tumors

Researchers have reported study results on a novel multireceptor-targeted somatostatin analogue called pasireotide (SOM230). The Phase II, open-label, multicenter study in patients with advanced neuroendocrine tumors (NET) whose symptoms were no longer responsive to octreotide LAR therapy found that the drug was effective and well tolerated in controlling patient symptoms.

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Study of Everolimus Treatment in Newly-diagnosed Patients With Advanced Gastrointestinal Neuroendocrine Tumors

Conditions :   Gastrointestinal Tumors;   Pancreatic Tumors;   Gastrointestinal Neuroendocrine Tumors;   Pancreatic Neuroendocrine Tumors Intervention :   Drug: Everolimus Sponsors :   Hellenic Cooperative Oncology Group;   Hellenic Cooperative Oncology Group;   Novartis Hellas Not yet recruiting – verified July 2012

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Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer or Metastatic Large Cell Neuroendocrine Non-Small Cell Lung Cancer

Conditions :   Lung Cancer;   Neuroendocrine Carcinoma Interventions :   Drug: cisplatin;   Drug: etoposide;   Drug: veliparib;   Other: placebo Sponsors :   National Cancer Institute (NCI);   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI) Not yet recruiting – verified July 2012

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Efficacy and Safety of BEZ235 Compared to Everolimus in Patients With Advanced Pancreatic Neuroendocrine Tumors

Condition :   Pancreatic Neuroendocrine Tumors (pNET) Interventions :   Drug: BEZ235;   Drug: Everolimus Sponsors :   Novartis;   Novartis Pharmaceuticals Not yet recruiting – verified June 2012

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Safety and Efficacy of 68Ga-DOTA-tyr3-Octreotide

Conditions :   Neuroendocrine Tumors;   Carcinoid Tumors;   Neuroblastoma;   Medulloblastoma Intervention :   Drug: 68Ga-DOTATOC PET/C Sponsors :   University of Iowa;   University of Iowa Recruiting – verified June 2012

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Potential Imaging and Molecular Predictors of Response to Novel Therapies in Metastatic Pancreatic Neuroendocrine Tumors

Condition :   Pancreatic Neuroendocrine Cancer Intervention :   Other: MRI Sponsors :   Memorial Sloan-Kettering Cancer Center;   Memorial Sloan-Kettering Cancer Center Recruiting – verified May 2012

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Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced Neuroendocrine Tumors

Condition :   Neuroendocrine Tumors Intervention :   Drug: RAD001 Sponsors :   Novartis;   Novartis Pharmaceuticals Not yet recruiting – verified May 2012

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A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours

Conditions :   Carcinoid Tumor of the Small Bowel;   Neuroendocrine Tumour Interventions :   Drug: Octreotide;   Drug: Octreotide;   Drug: 177Lu-DOTA0-Tyr3-Octreotate Sponsors :   Advanced Accelerator Applications;   Pierrel Research Europe GmbH Not yet recruiting – verified April 2012

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