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In Preclinical Studies, New Drug Enhances Radiation Treatment For Brain Cancer

By on Thursday, May 16th, 2013 | No Comments

A novel drug may help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, report scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma multiforme (GBM), the new drug helped significantly extend survival when used in combination with radiation therapy…

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Discovery May Help Doctors Slow Progression And Recurrence Of Brain Cancer

By on Wednesday, October 24th, 2012 | No Comments

Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells…

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Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma

By on Monday, August 13th, 2012 | No Comments

Conditions :   Anaplastic Astrocytomas;   Anaplastic Oligodendrogliomas;   Glioblastomas (GBM) Intervention :   Drug: NKTR-102 Sponsors :   Stanford University;   Lawrence Recht;   Nektar Therapeutics Recruiting – verified August 2012

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UT Southwestern study suggests new treatment target for deadly brain tumors

By on Friday, August 3rd, 2012 | No Comments

A study by UT Southwestern Medical Center researchers published online in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies. Using a genetically engineered mouse model of glioblastoma multiforme (GBM), the researchers identified a subset of brain tumor cells that appear to be the source of cancer recurrence after therapy with the drug temozolomide. The UT Southwestern Medical Center is home to the Harold C. Simmons Cancer Center.

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Novel way to treat drug-resistant brain tumor cells

By on Sunday, June 3rd, 2012 | No Comments

New research explains why the incurable brain cancer, glioblastoma multiforme (GBM), is highly resistant to current chemotherapies.

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UCSF scientists develop a new potential therapeutic target for brain cancer

By on Friday, February 3rd, 2012 | No Comments

Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed. Researchers at the University of California, San Francisco, have now identified a potential new therapeutic target for the treatment of GBM.

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For Brain Cancer – A Thought-Provoking New Therapeutic Target?

By on Friday, February 3rd, 2012 | No Comments

Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed…

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Novel brain tumor vaccine acts like bloodhound to locate cancer cells

By on Friday, January 6th, 2012 | No Comments

A national U.S. clinical trial testing the efficacy of a novel brain tumor vaccine has begun. The vaccine will be tested in patients with newly diagnosed glioblastoma multiforme (GBM), the most aggressive and highest grade malignant glioma.

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Brain Tumor Chemotherapy Resistance Prediction

By on Tuesday, December 13th, 2011 | No Comments

Glioblastoma multiforme (GBM) is the most common and lethal of all human brain tumors that originate in the brain. For most patients, treatment involves surgery followed by both radiation therapy and chemotherapy with temozolomide. However, many GBMs are resistant to the effects of temozolomide…

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Understanding How Brain Tumors Invade

By on Tuesday, December 13th, 2011 | No Comments

Scientists have pinpointed a protein that allows brain tumors to invade healthy brain tissue, according to work published this week in the Journal of Experimental Medicine*. 40% of a common but deadly type of brain tumor – called glioblastoma multiforme (GBM) – have mutations in a gene that encodes a protein called epidermal growth factor receptor (EGFR)…

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