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Posts Tagged ‘activity’


New Study Reveals Important Mechanism For Tumorigenesis

Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis. A category of genes, called oncogenes, is critical during cancer progression, as they codify proteins whose activity favours the development of cancer…

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MicroRNA cooperation mutes breast cancer oncogenes

A new study shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects.

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Scientists discover how a protein finds its way

Scientists have uncovered how an enzyme co-factor can bestow specificity on a class of proteins with otherwise nonspecific biochemical activity. Proteins can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.

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Scientists discover new way protein degradation is regulated

Researchers have identified the mechanism by which the cell’s proteasome ramps up its activity to take care of unwanted and potentially toxic proteins. The finding has implications for treating muscle wasting and neurodegeneration, and suggests that small molecule inhibitors of this mechanism may be clinically useful in treating multiple myeloma.

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Improving The Antitumor Activity Of Interferon

Interferons have antitumor activity and have been used to treat a variety of malignancies, including colorectal and ovarian cancers. However, their effectiveness varies…

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Roche immune therapy cancer drug shows promise in early study

An experimental drug that spurs the immune system to fight cancer appeared to be safe and demonstrated anti-tumor activity against a variety of cancers in a small early stage study, researchers said on Tuesday.

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Potential Novel Type Of Therapy For Ovarian Cancer

A new antibody-guided drug has shown promising activity in a phase I trial involving ovarian cancer patients with platinum drug-resistant disease, researchers from Dana-Farber Cancer Institute reported at the annual meeting of the American Association for Cancer Research…

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New type of experimental drug active in platinum-resistant ovarian cancers

The antibody-drug conjugate DMUC5754A, a novel member of a relatively new class of drugs, showed activity in women with ovarian cancer, even those with hard-to-treat, platinum-resistant disease, in a phase I trial. Those women with the highest expression of the drug’s target, MUC16, gained the most benefit from treatment, which may help researchers predict which patients will benefit from treatment.

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Prostate cancer treatment study changing the way doctors practice

A new article recommends a dramatic shift in treating metastatic prostate cancer. Hormone therapy has been shown to extend the lives of patients, but it causes unpleasant side effects in men like moodiness, hot flashes, bone loss and sexual dysfunction. To relieve patients, doctors “pulsed” the therapy — giving it for a time and then stopping until signs of prostate cancer activity reappear. The study shows that continuous therapy helps more.

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One specific microRNA promotes tumor growth and cancer spread

Researchers have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity.

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