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Archive for August 19th, 2012


Know The Risk Factors Of Cancer

Cancer is one of the main reasons for death world-wide. It is from the unusual development of cells within your body and can easily have an affect on nearly every part of the body. Widespread kinds of cancer malignancy include carcinoma of the lung, breast cancer, liver cancer or liver cirrhosis and numerous others. Wherever [...]

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For Folmer, optimism prevails

Pennsylvania Sen. Mike Folmer, whose 48th District includes Lebanon County, speaks recently to the Lebanon Daily News editorial board.

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Market and Product Forecasts: HER2-Negative/Hormone Receptor-Positive Breast Cancer -

The treatment of HER2-negative/hormone receptor-positive breast cancer consists largely of genericized cytotoxic and antihormonal therapies.

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Recognize cancer signs & symptoms in your dog for earliest trreatment

No one wants to hear the word Cancer, especially when referring to your own family, friends and your pets that are indeed a part of the family.

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Ohio State studies find combination peptide therapies might offer more effective, less toxic cancer treatment

Two studies suggest that two peptide agents used either together or individually with a low-dose of a standard chemotherapy drug might offer more effective cancer therapy than current standard single-drug treatments. The studies used animal models of breast cancer to show that the peptide combinations dramatically delay tumor onset and progression by both inhibiting tumor growth and blocking the formation of new tumor blood vessels, say researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

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UNC mouse study finds clear linkages between inflammation, bacterial communities and cancer

A significant disturbance in the human body can profoundly alter the makeup of otherwise stable microbial communities co-existing within it, and changes in the internal ecology known as the human microbiome can result in unexpected and drastic consequences for human health. A report published in the August 16 online edition of the journal Science gives evidence for such a chain reaction. It has long been known that gut inflammation is a risk factor for cancer. The new study suggests that this may be in part because inflammation disturbs gut ecosystems leading to conditions that allow pathogens to invade the gut. These pathogens may damage host cells increasing the risk of the development of colorectal cancer.

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UNC study finds B cell survival holds key to chronic graft vs. host disease

In a paper published online August 15 by the journal, Blood, a team from the University of North Carolina’s Lineberger Comprehensive Cancer Center, shows in the laboratory that B cells from patients with chronic Graft vs. Host Disease are much more active than cells from patients without the disease. The team also outlines the cell signaling pathways that contribute to this increased activity – identifying a promising target for developing new therapies for the diseases.

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DNA deletions promote cancer, but collateral damage makes it vulnerable

Genomic deletions promote cancer by carving up or eliminating tumor-suppressor genes, but now scientists report in the journal Nature that the collateral damage they inflict on neighboring genes exposes cancer cells to vulnerabilities and new avenues for attack. Working with cell lines of glioblastoma multiforme, the most lethal type of brain tumor, researchers from the Dana-Farber Cancer Institute at Harvard Medical School, and some now at The University of Texas MD Anderson Cancer Center, found that collateral deletion of a gene vital to tumor metabolism allowed them to kill malignant cells by blocking another gene that redundantly performs the same function.

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MD Anderson-led study finds metabolic protein wields phosphate group to activate cancer-promoting genes

A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell. Working in cell lines and mouse models of glioblastoma multiforme, the most lethal form of brain tumor, the team showed that pyruvate kinase M2 (PKM2) fuels tumor growth by influencing a histone protein.

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Molecular Signature Used To Predict Radiation Therapy Benefit Validated By Moffitt Cancer Center Researchers, Colleagues

Researchers at Moffitt Cancer Center, working with colleagues in Sweden, the Netherlands and Puerto Rico, have validated a radiosensitivity molecular signature that can lead to better radiation therapy decisions for treating patients with breast cancer. The results appeared in a recent issue of Clinical Cancer Research, a publication of the American Association for Cancer Research…

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