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Archive for June 13th, 2012


Study Shows First Effective Drug for Cancer Patients with Peripheral Neuropathy

Results of a phase III trial (CALGB-170601) show that duloxetine (Cymbalta) effectively treats painful peripheral neuropathy caused by certain types of chemotherapy.

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Preoperative Chemotherapy, Radiation Improve Survival in Esophageal Cancer

Patients with esophageal cancer who received chemotherapy and radiation before surgery survived, on average, nearly twice as long as patients treated with surgery alone. The findings, from a large randomized trial of neoadjuvant chemoradiotherapy for the disease, were published May 31 in the New England Journal of Medicine.

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Pertuzumab Approved to Treat Some Metastatic Breast Cancers

The Food and Drug Administration (FDA) has approved pertuzumab (Perjeta) to treat women with HER2-positive breast cancer that has spread to other parts of the body. Pertuzumab is approved for use in combination with trastuzumab (Herceptin), another anti-HER2 therapy, and the chemotherapy drug docetaxel (Taxotere) to treat women who have not received previous anti-HER2 therapy or chemotherapy.

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Global Cancer Burden Expected to Shift

Researchers from the International Agency for Research on Cancer (IARC) estimate that 16 percent, or around 2 million, of the 12.7 million new cancer cases diagnosed in 2008 were caused by infectious agents (viruses, bacteria, and parasites).

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An Observational Study of Avastin (Bevacizumab) in Patients With Glioblastoma Multiforme in First or Second Relapse

Condition :   Glioblastoma Multiforme Intervention :   Sponsors :   Hoffmann-La Roche;   Hoffmann-La Roche Not yet recruiting – verified June 2012

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Correlation of Bispectral Index Score and Total Intravenous Anesthesia (TIVA)

Conditions :   Gynecology for Benign/Malignant Neoplasm.;   Long Bone Fracture Intervention :   Drug: propofol Sponsors :   University of Medicine and Dentistry New Jersey;   University of Medicine and Dentistry New Jersey Recruiting – verified June 2012

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Radiation Therapy With Sorafenib for TACE-Resistant Hepatocellular Carcinoma

Conditions :   Hepatocellular Carcinoma;   Hepatocellular Cancer;   Hepatoma;   Liver Cancer Interventions :   Drug: Sorafenib;   Radiation: Conventional fractionation (2 Gy per day) external beam radiation therapy Sponsors :   Medical College of Wisconsin;   Medical College of Wisconsin Not yet recruiting – verified June 2012

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Prospective Registry Of MammaPrint in Patients With an Intermediate Recurrence Score

Condition :   Hormone Receptor Positive Malignant Neoplasm of Breast Intervention :   Device: MammaPrint Sponsors :   Agendia;   Agendia Recruiting – verified June 2012

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Tumor Specific Plasma DNA in Breast Cancer

Condition :   Breast Cancer Intervention :   Sponsors :   Dartmouth-Hitchcock Medical Center;   Dartmouth-Hitchcock Medical Center Not yet recruiting – verified June 2012

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Radium(223) Chloride (Alpharadin) in Castration-Resistant (Hormone-Refractory) Prostate Cancer Patients With Bone Metastases

Condition :   Prostatic Neoplasms Intervention :   Drug: Radium-223 chloride (BAY88-8223) Sponsors :   Bayer;   Bayer Not yet recruiting – verified June 2012

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