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Archive for May 24th, 2012


Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury

Conditions :   Traumatic Brain Injury;   Subdural Hematoma;   Cerebral Contusion;   Head Injury;   Cerebral Edema Interventions :   Drug: Induced, sustained hypernatremia using hypertonic saline;   Drug: Standard of care (hypertonic saline and mannitol; serum sodium) Sponsors :   Massachusetts General Hospital;   Massachusetts General Hospital Not yet recruiting – verified May 2012

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Phase 2 Study of the Poly(ADP-Ribose) Polymerase Inhibitor E7016 in Combination With Temozolomide in Subjects With Wild Type BRAF Stage IV or Unresectable Stage III Melanoma

Conditions :   Wild Type BRAF Stage IV Melanoma;   Unresectable Stage III Melanoma Interventions :   Drug: E7016;   Drug: E7016 plus TMZ Sponsors :   Eisai Inc.;   Eisai Inc. Recruiting – verified May 2012

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Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer

Condition :   Colorectal Neoplasms Intervention :   Other: Serum proteomics Sponsors :   Fudan University;   Fudan University Completed – verified May 2012

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The Optimal Oblique and Axial Angle of Fluoroscope for Superior Hypogastric Plexus Block

Conditions :   Chronic Pelvic Pain;   Pelvic Malignancy;   Superior Hypogastric Plexus Block Intervention :   Sponsors :   Samsung Medical Center;   Samsung Medical Center Recruiting – verified May 2012

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Study on FOLFOX6 as First-line Therapy to Treat Recurrent or Metastatic Esophageal Cancer

Condition :   Esophageal Squamous Cell Carcinoma Intervention :   Drug: FOLFOX6 Sponsors :   Fudan University;   Fudan University Completed – verified May 2012

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Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI

Condition :   Advanced Adenocarcinoma of the Colon or Rectum Interventions :   Drug: FOLFIRI.;   Drug: Atorvastatin Sponsors :   UNC Lineberger Comprehensive Cancer Center;   UNC Lineberger Comprehensive Cancer Center Recruiting – verified May 2012

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A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064 AM2)

Condition :   Breast Neoplasms Interventions :   Drug: Ridaforolimus;   Drug: Dalotuzumab;   Drug: Exemestane Sponsors :   Merck;   Merck Not yet recruiting – verified May 2012

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High Dose Rate Prostate Brachytherapy: Dose Escalation to Dominant Intra-prostatic Nodule

Condition :   Prostate Cancer Intervention :   Radiation: HDR interstitial brachytherapy Sponsors :   British Columbia Cancer Agency;   British Columbia Cancer Agency Not yet recruiting – verified May 2012

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Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma

Condition :   Head and Neck Cancer Interventions :   Drug: Akt inhibitor MK2206;   Other: laboratory biomarker analysis Sponsors :   National Cancer Institute (NCI);   Cancer and Leukemia Group B;   National Cancer Institute (NCI) Not yet recruiting – verified May 2012

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Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100

Conditions :   Prostate Cancer;   Castration Resistant Prostate Cancer;   Pain;   Prostatic Neoplasms Interventions :   Drug: cabozantinib;   Drug: prednisone Sponsors :   Exelixis;   Exelixis Not yet recruiting – verified May 2012

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