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Archive for May 16th, 2012


Studies Support Expanded Role for Lenalidomide in Treating Multiple Myeloma

Maintenance therapy with the drug lenalidomide (Revlimid) substantially lengthens the time patients with multiple myeloma live without their cancers progressing, according to the results of three randomized placebo-controlled clinical trials published May 10 in the New England Journal of Medicine.

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Sequencing Study Identifies Gene that May Contribute to Melanoma

A whole-genome sequencing study of metastatic melanoma tumor samples has identified a gene, PREX2, that appears to be commonly mutated in melanoma and may play a role in driving the cancer’s growth and spread.

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NIH, Industry, and Researchers Collaborate to Find New Uses for Existing Drugs

NIH’s National Center for Advancing Translational Sciences (NCATS) recently unveiled a collaborative program that will allow researchers to find new uses for existing drug compounds.

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Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp

Condition :   Actinic Keratosis Interventions :   Drug: Ingenol mebutate gel, 0.015%;   Drug: Vehicle gel Sponsors :   LEO Pharma;   LEO Pharma Recruiting – verified May 2012

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Study of Azacitidine to Evaluate Safety and Effectiveness for Chinese Patients With Higher Risk Myelodysplastic Syndrome

Condition :   Myelodysplastic Syndrome (MDS) Intervention :   Drug: Azacitidine Sponsors :   Celgene Corporation;   Celgene Corporation;   PRA International Not yet recruiting – verified May 2012

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A Study to Evaluate the Efficacy and Safety of Ibrutinib, in Patients With Mantle Cell Lymphoma Who Progress After Bortezomib Therapy

Condition :   Mantle Cell Lymphoma Intervention :   Drug: Ibrutinib Sponsors :   Janssen Research & Development, LLC;   Janssen Research & Development, LLC Not yet recruiting – verified May 2012

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Influence of U-relax on Vaginal Health Promotion and HPV DNA Test Change From Positive to Negative

Conditions :   Human Papillomavirus;   Vaginal Infection Intervention :   Dietary Supplement: U-relax Sponsors :   Chang Gung Memorial Hospital;   Chang Gung Memorial Hospital Recruiting – verified April 2012

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Revlimid® as Consolidation Treatment Chronic Lymphocytic Leukemia

Condition :   Chronic Lymphocytic Leukemia Intervention :   Drug: Lenalidomide Sponsors :   University of California, San Diego;   Thomas Kipps;   Celgene Corporation Recruiting – verified May 2012

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Detection of Liver Fibrosis With Magnetic Resonance Imaging (MRI)

Condition :   Chronic Liver Disease Intervention :   Drug: Perfusion MRI (adofosveset trisodium, Ablavar, Lantheus) Sponsors :   Mount Sinai School of Medicine;   Bachir Taouli Recruiting – verified May 2012

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This Trial is a Randomized, Open-label Two-arm Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell…

Condition :   Primary Mediastinal B-cell Lymphoma Interventions :   Other: observation;   Radiation: 3D-Conformal Radiotherapy (3D-CRT) Sponsors :   International Extranodal Lymphoma Study Group (IELSG);   International Extranodal Lymphoma Study Group (IELSG) Recruiting – verified May 2012

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