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Archive for April 4th, 2012


Transplant Recipients at Higher Risk of Aggressive Form of Lymphoma

Recipients of solid organ transplants are about 14 times more likely than the general population to develop diffuse large B-cell lymphoma (DLBCL), an aggressive type of non-Hodgkin lymphoma (NHL). This finding and additional data from a comprehensive study of risk factors for this NHL subtype in transplant recipients were presented at the 2012 American Association for Cancer Research annual meeting .

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Targeted Drug Shows Promise in Common Form of Lymphoma

Preliminary results from two early-phase clinical trials suggest that the investigational drug ibrutinib may benefit some patients with an aggressive type of non-Hodgkin lymphoma (NHL). In the trials, some patients with diffuse large B-cell lymphoma (DLBCL) who did not respond to standard therapies, or who had stopped responding to these treatments, experienced complete or substantial tumor shrinkage after treatment with ibrutinib.

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Some Melanoma Cells May Use the Body’s Immune Response to Escape Destruction

Researchers have found evidence that some melanomas may use a protein induced by T cells—a type of immune cell that can attack cancer cells—to evade the immune system. The retrospective study involving tumor samples from 150 patients suggests that this protein, called B7-H1, suppresses T cells, ultimately preventing the immune system from destroying the cancer cells.

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Olaparib Delays Progression of Ovarian Cancer after Initial Treatment

Long-term therapy with the targeted drug olaparib significantly improved progression-free survival among women with the most common type of ovarian cancer in a randomized, placebo-controlled phase II clinical trial.

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Methylation Levels in HPV DNA May Indicate Risk for Cervical Precancer

A new study suggests that human papillomavirus (HPV) DNA methylation levels could be used as a biomarker to predict which cervical HPV infections are most likely to progress to cervical precancer.

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New method yields insulin-producing pancreatic cell clusters

Three-dimensional clusters of pancreatic beta-cells that live much longer and secrete more insulin than single cells grown in the laboratory are valuable new tools for studying pancreatic diseases such as diabetes and for testing novel therapies. Growing pancreatic cells in the laboratory is challenging, in part because to survive and function normally they require cell-cell contact.

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Prostate cancer: Gleason Score

Prostate cancer: Gleason Score. An introduction to the Gleason Grading System for prostate cancer.

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Prospective Study on Severe Infections on Acute Myeloid Leukemia (AML) Patients

Conditions :   AML;   Adult Intervention :   Other: Observation Sponsor :   Gruppo Italiano Malattie EMatologiche dell’Adulto Not yet recruiting – verified April 2012

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Effect of the New Norwegian Food Based Dietary Guidelines on Chronic Diseases in Colorectal Cancer Survivors

Condition :   Colorectal Cancer Intervention :   Other: new norwegian food based dietary guidelines Sponsors :   University of Oslo;   Oslo University Hospital;   National Institute for Health and Welfare, Finland;   University Hospital, Akershus;   Asker & Baerum Hospital;   Sykehuset Buskerud HF;   Norwegian Cancer Society;   The Research Council of Norway Recruiting – verified March 2012

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Safety and Efficacy Study of Bendamustine to Treat Non-Hodgkin Lymphoma

Condition :   Non-Hodgkin Lymphoma by Clinical Course Intervention :   Drug: Bendamustine Sponsor :   Shandong Lanjin Pharmaceuticals Co.,Ltd Recruiting – verified March 2012

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