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Archive for February 14th, 2012

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An Open-Label Phase 2 Study of Ofatumumab (Arzerra) in Combination With Oral GSK2110183 in the Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL)

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Condition :   Chronic Lymphocytic Leukemia (CLL) Intervention :   Drug: Ofatumumab with GSK2110183 Sponsors :   University Health Network, Toronto;   GlaxoSmithKline Recruiting – verified February 2012

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Prevention of UV-induced Infections and Carcinogenic Skin Alterations in Immunosuppressed Outpatients After Solid Organ Transplantations

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Conditions :   Actinic Keratoses;   Squamous Cell Carcinomas Interventions :   Device: MD-3511356;   Other: Standard Sun Protection Measures Sponsor :   Spirig Pharma Ltd. Recruiting – verified February 2012

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Saliva, Hyperbaric Oxygen Therapy, & Gland Function: A Prospective Study

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Conditions :   Osteoradionecrosis of the Jaw;   Xerostomia Intervention :   Sponsor :   Loma Linda University Not yet recruiting – verified February 2012

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Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma

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Conditions :   Adult Alveolar Soft-part Sarcoma;   Adult Angiosarcoma;   Adult Desmoplastic Small Round Cell Tumor;   Adult Epithelioid Hemangioendothelioma;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Fibrous Histiocytoma;   Adult Malignant Hemangiopericytoma;   Adult Malignant Mesenchymoma;   Adult Neurofibrosarcoma;   Adult Rhabdomyosarcoma;   Adult Synovial Sarcoma;   Childhood Alveolar Soft-part Sarcoma;   Childhood Angiosarcoma;   Childhood Desmoplastic Small Round Cell Tumor;   Childhood Epithelioid Hemangioendothelioma;   Childhood Epithelioid Sarcoma;   Childhood Fibrosarcoma;   Childhood Leiomyosarcoma;   Childhood Liposarcoma;   Childhood Malignant Hemangiopericytoma;   Childhood Malignant Mesenchymoma;   Childhood Neurofibrosarcoma;   Childhood Synovial Sarcoma;   Dermatofibrosarcoma Protuberans;   Metastatic Childhood Soft Tissue Sarcoma;   Nonmetastatic Childhood Soft Tissue Sarcoma;   Recurrent Adult Soft Tissue Sarcoma;   Recurrent Childhood Soft Tissue Sarcoma;   Stage III Adult Soft Tissue Sarcoma;   Stage IV Adult Soft Tissue Sarcoma Interventions :   Drug: gemcitabine hydrochloride;   Drug: pazopanib hydrochloride;   Other: placebo;   Other: laboratory biomarker analysis Sponsors :   OHSU Knight Cancer Institute;   National Cancer Institute (NCI);   GlaxoSmithKline Not yet recruiting – verified January 2012

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A Two-Step Approach to Bone Marrow Transplant Using Cells From Two Partially-Matched Relatives

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Conditions :   Hematologic Malignancy;   Leukemia;   Acute Lymphoblastic Leukemia;   ALL;   Acute Myelogenous Leukemia;   AML;   Chronic Lymphocytic Leukemia;   CLL;   Lymphoma;   Hodgkin’s Lymphoma;   Non-hodgkin’s Lymphoma;   Myeloma Interventions :   Radiation: Total Body Irradiation (TBI);   Biological: Donor Lymphocyte Infusion (DLI);   Drug: Cyclophosphamide (CY);   Drug: Tacrolimus;   Drug: Mycophenolate Mofetil (MMF);   Biological: Hematopoietic Stem Cell Transplant (HSCT) Sponsor :   Thomas Jefferson University Not yet recruiting – verified February 2012

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Erlotinib With or Without Bevacizumab in Treating Patients With Stage IV Non-Small Cell Lung Cancer With EGFR Mutations

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Condition :   Stage IV Non-small Cell Lung Cancer Interventions :   Drug: erlotinib;   Biological: bevacizumab;   Other: laboratory biomarker analysis Sponsor :   Academic and Community Cancer Research United Not yet recruiting – verified February 2012

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Tobacco Dependence in Breast Cancer Patients Scheduled for Mastectomy/Reconstructive Surgery Trial of Varenicline (Chantix)

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Conditions :   Breast Cancer;   Tobacco Dependence Interventions :   Drug: placebo;   Drug: varenicline Sponsors :   Memorial Sloan-Kettering Cancer Center;   Pfizer Recruiting – verified February 2012

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Differences Between Primary And Recurrent Ovarian Cancers Revealed By Molecular Profiling

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There is a need to analyze tumor specimens at the time of ovarian cancer recurrence, according to a new study published in Molecular Cancer Therapeutics. Researchers used a diagnostic technology called molecular profiling to examine the differences in the molecular characteristics of primary and recurrent ovarian tumors and found significant changes for some biomarkers…

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Army doctor develops breast cancer vaccine

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Kellie Trombitas fought through surgery and two rounds of chemotherapy for 10 long, difficult months before she was declared cancer-free Dec.

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Most Women With Breast Cancer Want a Role in Medical Decisions

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Breast cancer patients aren’t getting the control over their own bodies they would like, new research finds.

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