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Archive for December 16th, 2011


Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient

Patients who receive a blood stem cell transplant from a donor outside of their family to treat leukemia and other blood diseases are more likely to have graft failure but less likely to experience graft-versus-host disease, a condition caused by the donor cells attacking the recipient’s body, if the transplanted blood cells come directly from a donor’s bone marrow, rather than from blood stem cells circulating in the donor’s bloodstream (PBSCs), according to new research.

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Accuracy of Dilution of EUS-FNA Pancreatic Cyst Fluid for Carcinoembryonic Antigen (CEA) Measurement

Condition :   Pancreatic Cyst Intervention :   Other: Laboratory processing for results Sponsor :   University of California, Irvine Enrolling by invitation – verified December 2011

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Efficacy Study & Safety Evaluation of SR-T100 Gel in Actinic Keratosis Treatment

Conditions :   Actinic Keratosis;   Skin Lesions;   Porokeratosis;   Porokeratosis, Disseminated Superficial Actinic 1;   Actinic Porokeratosis Interventions :   Drug: SR-T100 gel;   Drug: Vehicle gel Sponsors :   G&E Herbal Biotechnology Co., LTD;   Statplus Inc. (Taipei, Taiwan Republic of China) Recruiting – verified December 2011

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Phase II Study of Fractionated 90Y Ibritumomab Tiuxetan (Zevalin) Radioimmunotherapy as an Initial Therapy of Follicular Lymphoma

Condition :   Follicular Lymphoma Interventions :   Drug: 90Y Ibritumomab tiuxetan;   Drug: Rituximab Sponsors :   Christie Hospital NHS Foundation Trust;   Bayer Active, not recruiting – verified December 2011

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CDB-2914 for Abnormal Uterine Bleeding in Premenopausal Women

Condition :   Urogenital Abnormalities Intervention :   Drug: CDB-2914 Sponsor :   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Recruiting – verified September 2011

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Administration of Donor T Cells With the Caspase-9 Suicide Gene

Conditions :   Acute Lymphoblastic Leukemia;   Myelodysplastic Syndrome;   Acute Myeloid Leukemia;   Chronic Myelogenous Leukemia;   Non Hodgkin Lymphoma;   Hemophagocytic Lymphohistiocytosis;   Familial Hemophagocytic Lymphohistiocytosis;   Hemophagocytic Syndrome;   Epstein Barr Virus Infection;   X-linked Lymphoproliferative Disease Intervention :   Drug: AP1903 Sponsors :   Baylor College of Medicine;   Texas Children’s Hospital;   The Methodist Hospital System Not yet recruiting – verified December 2011

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Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant Ovarian Cancer

Conditions :   Recurrent Ovarian Epithelial Cancer;   Recurrent Ovarian Germ Cell Tumor;   Malignant Tumor of Peritoneum;   Stage IV Ovarian Epithelial Cancer;   Stage IV Ovarian Germ Cell Tumor Interventions :   Radiation: stereotactic body radiation therapy;   Procedure: positron emission tomography;   Procedure: computed tomography;   Other: questionnaire administration;   Radiation: fludeoxyglucose F 18 Sponsor :   Stanford University Not yet recruiting – verified December 2011

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A Phase I Study of CD19 Specific T Cells in CD19 Positive Malignancy

Condition :   CD19 Positive Non-Hodgkin Lymphoma Intervention :   Genetic: aCD19z cells, IL2, pre conditioning Cyclophosphamide & Fludarabine Sponsor :   Christie Hospital NHS Foundation Trust Suspended – verified June 2009

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Study Evaluating the Safety and Efficacy Of Carboplatin/Paclitaxel And Carboplatin/Paclitaxel/Bevacizumab With and Without GDC-0941 in Patients With Previously Untreated Advanced Or Recurrent Non-small Cell Lung Cancer

Condition :   Non-Small Cell Lung Cancer Interventions :   Drug: GDC-0941;   Drug: carboplatin;   Drug: paclitaxel;   Drug: bevacizumab;   Drug: Placebo Sponsor :   Genentech Not yet recruiting – verified December 2011

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Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma

Condition :   Neuroblastoma Interventions :   Genetic: fluorescence in situ hybridization;   Genetic: gene expression analysis;   Genetic: microarray analysis;   Genetic: mutation analysis;   Genetic: protein analysis;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Other: microscopy Sponsors :   Children’s Oncology Group;   National Cancer Institute (NCI) Not yet recruiting – verified December 2011

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